Synthesis of C-5'-nor-dideoxycarbanucleosides structurally related to neplanocin C.

M J Comin, C A Pujol, E B Damonte, J B Rodriguez

Index: Nucleosides Nucleotides 18(10) , 2219-31, (1999)

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Abstract

Purine carbanucleosides built on a 6-oxabicyclo[3.1.0]hexane template were synthesized from readily available 2-cyclopentenone employing a Mitsunobu reaction to incorporate the base onto the carbocyclic ring. Both adenosine and guanosine analogues exhibited moderate antiviral activity.