Organic & Biomolecular Chemistry 2012-02-14

Direct amination of α-substituted nitroacetates using di-tert-butyl azodicarboxylate catalyzed by Hatakeyama's catalyst β-ICD.

Cong-Bin Ji, Yun-Lin Liu, Xiao-Li Zhao, Yin-Long Guo, Hao-Yang Wang, Jian Zhou

Index: Org. Biomol. Chem. 10(6) , 1158-61, (2012)

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Abstract

We report the first example of catalytic asymmetric direct amination of α-monosubstituted nitroacetates using di-tert-butyl azodicarboxylate. The simple and easily available Hatakeyama's catalyst β-ICD 11 was found to be a highly enantioselective catalyst for this reaction.

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