Angewandte Chemie. International edition in English 2015-07-06

Catalytic Enantioselective Reaction of α-Aminoacetonitriles Using Chiral Bis(imidazoline) Palladium Catalysts.

Masaru Kondo, Tomoki Nishi, Tsubasa Hatanaka, Yasuhiro Funahashi, Shuichi Nakamura

Index: Angew. Chem. Int. Ed. Engl. 54(28) , 8198-202, (2015)

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Abstract

The catalytic enantioselective reaction of diphenylmethylidene-protected α-aminoacetonitriles with imines has been developed. Good yields and diastereo- and enantioselectivities were observed for the reaction of various imines using chiral bis(imidazoline)/Pd catalysts. The reaction of α-aminonitriles with di-tert-butyl azodicarboxylate afforded chiral α,α-diaminonitriles in high yields with high enantioselectivities. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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