[New adamantane derivatives and ways of overcoming the resistance of influenza A viruses to rimantadine and amantadine].

V A Shibnev, T M Garayev, M P Finogenova, E S Shevchenko, E I Burtseva

Index: Vopr. Virusol. 56(2) , 36-9, (2011)

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Abstract

The amino acid and peptide derivatives of 1-adamantane carboxylic acid and rimantadine (18 compounds) have been first synthesized and investigated for their activity against influenza A virus (H1N1, H1N1v). In a series of obtained adamantine derivatives, some compounds have been found to be able to inhibit rimantadine-resistant influenza A virus strains. Thus, the antiviral properties of rimantadine can be restored.