Structural Optimization of Berberine as a Synergist to Restore Antifungal Activity of Fluconazole against Drug??Resistant Candida albicans
…, W Liu, S Chen, C Wei, C Zang, S Tian, J Yang…
Index: Liu, Hong; Wang, Liang; Li, Yan; Liu, Jiang; An, Maomao; Zhu, Shaolong; Cao, Yongbing; Jiang, Zhihui; Zhao, Mingzhu; Cai, Zhan; Dai, Li; Ni, Tingjunhong; Liu, Wei; Chen, Simin; Wei, Changqing; Zang, Chengxu; Tian, Shujuan; Yang, Jingyu; Wu, Chunfu; Zhang, Dazhi; Liu, Hua; Jiang, Yuanying ChemMedChem, 2014 , vol. 9, # 1 p. 207 - 216
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Citation Number: 4
Abstract
Abstract We have conducted systematic structural modification, deconstruction, and reconstruction of the berberine core with the aim of lowering its cytotoxicity, investigating its pharmacophore, and ultimately, seeking novel synergistic agents to restore the effectiveness of fluconazole against fluconazole-resistant Candida albicans. A structure–activity relationship study of 95 analogues led us to identify the novel scaffold of N-(2-(benzo [d][1, ...
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