Enantioselective synthesis of trifluoromethyl-substituted cyclopropanes.
Justin R Denton, Dinesh Sukumaran, Huw M L Davies
Index: Org. Lett. 9 , 2625, (2007)
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Abstract
The reaction of 1-aryl-2,2,2-trifluorodiazoethanes with alkenes, catalyzed by the adamantylglycine-derived dirhodium complex Rh2(R-PTAD)4, generates trifluoromethyl-substituted cyclopropanes with high diastereoselectivity (>94%) and enantioselectivity (88->98%).
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