Design and synthesis of 2-phenoxynicotinic acid hydrazides as anti-inflammatory and analgesic agents.

Alireza Moradi, Latifeh Navidpour, Mohsen Amini, Hamid Sadeghian, Hooman Shadnia, Omidreza Firouzi, Ramin Miri, Seyed Esmaeil Sadat Ebrahimi, Mohammad Abdollahi, Mona Haddad Zahmatkesh, Abbas Shafiee

Index: Arch. Pharm. (Weinheim) 343(9) , 509-18, (2010)

Full Text: HTML

Abstract

A series of 2-phenoxynicotinic acid hydrazides were synthesized and evaluated for their analgesic and anti-inflammatory activities. Several compounds having an unsubstituted phenyl/4-pyridyl or C-4 methoxy substituent on the terminal phenyl ring showed moderate to high analgesic or anti-inflammatory activity in comparison to mefenamic acid as the reference drug. The compounds with highest anti-inflammatory activity were subjected to in vitro COX-1/COX-2 inhibition assays and showed moderate to good COX-1 and weak COX-2 inhibition activities.