Chromatographic behavior of the enantiomers of 2,2,2-trifluoro-1-(9-anthryl)ethanol on a quinidine-carbamate chiral stationary phase.

Leonid Asnin, Gustaf G__tmar, Georges Guiochon

Index: J. Chromatogr. A. 1091(1-2) , 183-6, (2005)

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Abstract

The enantioseparation of 2,2,2-trifluoro-1-(9-anthryl)ethanol on silica-bonded quinidine carbamate was examined under linear chromatographic conditions. The significant impact of nonselective adsorption on the retention was demonstrated. The influences of a polar additive in the mobile phase on the retention, the selectivity and the thermodynamic quantities of the retention were measured. A small effect of the pressure on the selectivity and on the accuracy of the thermodynamic measurements was observed.