Archives of Pharmacal Research 2006-06-01

Synthesis and evaluation of biological properties of benzylideneacetophenone derivatives.

Seikwan Oh, Soyong Jang, Donghyun Kim, Inn-Oc Han, Jae-Chul Jung

Index: Arch. Pharm. Res. 29(6) , 469-75, (2006)

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Abstract

A series of yakuchinone B 1f and its analogs 1a-e was synthesized and evaluated for free radical scavenging, suppression of LPS-induced NO generation, cytotoxicity and anti-excitotoxicity in vitro. Compound 1c exhibited potent anti-excitotoxicity, while all compounds 1a-f showed considerable effects of free radical scavenging, suppression of LPS-induced NO generation, and cytotoxicity in microglia.

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