7-Alkoxy-4-phenylamino-3-quinolinecar-bonitriles as dual inhibitors of Src and Abl kinases.

Diane H Boschelli, Yanong D Wang, Steve Johnson, Biqi Wu, Fei Ye, Ana Carolina Barrios Sosa, Jennifer M Golas, Frank Boschelli

Index: J. Med. Chem. 47(7) , 1599-601, (2004)

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Abstract

We previously reported that several 7-alkoxy-4-phenylamino-3-quinolinecarbonitriles were potent inhibitors of Src kinase activity. We disclose here a new highly efficient and versatile route to these compounds, which are also potent inhibitors of Abl kinase.