Influence of imidazole replacement in different structural classes of histamine H 3-receptor antagonists

…, S Elz, F Leurquin, CR Ganellin, JC Schwartz…

Index: Meier; Apelt; Reichert; Grassmann; Ligneau; Elz; Leurquin; Ganellin; Schwartz; Schunack; Stark European Journal of Pharmaceutical Sciences, 2001 , vol. 13, # 3 p. 249 - 259

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Citation Number: 93

Abstract

The reference compounds for histamine H3-receptor antagonists carry as a common feature an imidazole moiety substituted in the 4-position. Very recently novel ligands lacking an imidazole ring have been described possessing a N-containing non-aromatic heterocycle instead. In this study we investigated whether imidazole replacement, favourably by a piperidine moiety, is generally applicable to different structural classes of reference ...