Tetrahedron

Microwave-assisted synthesis of 4-amino-3, 5-dihalopyridines

M Pichowicz, S Crumpler, E McDonald, J Blagg

Index: Pichowicz, Mark; Crumpler, Simon; McDonald, Edward; Blagg, Julian Tetrahedron, 2010 , vol. 66, # 13 p. 2398 - 2403

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Citation Number: 8

Abstract

Recent years have seen the emergence of 4-amino-3,5-dihalopyridines as an important structural motif in medicinal chemistry; for example, as intermediates, which can be further functionalised through cross-coupling reactions 1 and as pharmaceutically active compounds across a range of disease areas. 2, 2a, 2b, 2c, 2d and 2e Approaches to these structures often commence with 4-amino-3,5-dichloropyridine and incorporate further functionality through ...