Organocatalysis approach to trifluoromethylation with fluoroform
Y Zhang, M Fujiu, H Serizawa, K Mikami
Index: Zhang, Yuan; Fujiu, Motohiro; Serizawa, Hiroki; Mikami, Koichi Journal of Fluorine Chemistry, 2013 , vol. 156, p. 367 - 371
Full Text: HTML
Citation Number: 12
Abstract
Abstract The organic base methodology exploits an access to generate the “trifluoromethyl anion” for carbonyl, ester, acid halide, epoxide, deuterium donor, and carbon dioxide substrates to afford the trifluoromethylation products with good overall efficiency even in organocatalysis conditions. The NMR analysis of the mixture of fluoroform and P 4-base shows no change thereof. However, on addition of electrophiles, the trifluoromethylation ...
Related Articles:
Effective nucleophilic trifluoromethylation with fluoroform and common base
[Russell, Jamie; Roques, Nicolas Tetrahedron, 1998 , vol. 54, # 45 p. 13771 - 13782]
Fluoro-substituted ketones from nitriles using acidic and basic reaction conditions
[Raja, Erum K.; Klumpp, Douglas A. Tetrahedron Letters, 2011 , vol. 52, # 40 p. 5170 - 5172]
[Barton, Derek H. R.; Jaszberenyi, Joseph Cs.; Theodorakis, Emmanouil A.; Reibenspies Journal of the American Chemical Society, 1993 , vol. 115, # 18 p. 8050 - 8059]
[Cheng, Huicheng; Pei, Yu; Leng, Faqiang; Li, Jingya; Liang, Apeng; Zou, Dapeng; Wu, Yangjie; Wu, Yusheng Tetrahedron Letters, 2013 , vol. 54, # 33 p. 4483 - 4486]
[Barton, Derek H. R.; Jaszberenyi, Joseph Cs.; Theodorakis, Emmanouil A.; Reibenspies Journal of the American Chemical Society, 1993 , vol. 115, # 18 p. 8050 - 8059]