Effective nucleophilic trifluoromethylation with fluoroform and common base
J Russell, N Roques
Index: Russell, Jamie; Roques, Nicolas Tetrahedron, 1998 , vol. 54, # 45 p. 13771 - 13782
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Citation Number: 76
Abstract
Common bases (alcoholate, dimsyl anion or amide) are able to deprotonate trifluoromethane to form a trifluoromethyl anion equivalent. In this reaction DMF plays a crucial role of stabilisation. Trifluoromethyl aryl alcohols, ketones or sulfides can be obtained in good yields with the new reagent CF3H/Base/DMF.
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