Synthesis and evaluation of antirhinovirus activity of 3-hydroxy and 3-methoxy 2-styrylchromones.
Nicoletta Desideri, Paola Mastromarino, Cinzia Conti
Index: Antivir. Chem. Chemother. 14(4) , 195-203, (2003)
Full Text: HTML
Abstract
Recently, we identified 2-styrylchromones as a new class of antirhinovirus flavonoids with moderate activity against both rhinovirus groups A and B. In order to improve the antiviral effect of the first series of tested 2-styrylchromones, a hydroxy or methoxy group was introduced in position 3 of the chromone ring. Cytotoxicity and antiviral activity of the new synthesized compounds were evaluated in HeLa cell cultures infected with rhinoviruses 1B and 14, selected as representative serotypes for viral groups B and A of human rhinoviruses (HRVs), respectively. These antiviral results compared to those obtained for 3-unsubstituted 2-styrylchromones indicate the greater potency of 3-hydroxy and 3-methoxy derivatives against both serotypes.
Related Compounds
Related Articles:
2001-01-01
[J. Org. Chem. 63(3) , 864-66, (1998)]
Catabolism of 2,7-dichloro- and 2,4,8-trichlorodibenzofuran by Sphingomonas sp strain RW1.
2001-01-01
[J. Ind. Microbiol. Biotechnol. 23(4-5) , 359-63, (1999)]
Synthesis and characterization of copper (II) complexes with a tridentate schiff base ligand derived from 5-chloro-2-hydroxyacetophenone and salicylhydrazide. X-ray structure of copper (II)(5-chloro-2-hydroxyacetophenone-salicylhydrazide) dimethylformamide. Dance JM, et al.
[Inorganica Chim. Acta 162(2) , 239-44, (1989)]
Studies on the Intramolecular Hydrogen Bond in Conjugated Systems by the Measurements of Dipole Moments. II. Salicylaldehyde and o-Hydroxyacetophenone Eda B and Ito K.
[Bull. Chem. Soc. Jpn. 30(2) , 164-67, (1957)]