Direct synthesis of unprotected phenols using palladium-catalysed cross coupling reactions of functionalised organozinc reagents.
Richard F W Jackson, Ian Rilatt, P John Murray
Index: Org. Biomol. Chem. 2(1) , 110-13, (2004)
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Abstract
Palladium-catalysed reaction of unprotected 2-, 3-, and 4-iodophenols with a range of amino acid derived organozinc reagents (not used in excess) gives the expected products in good to excellent yield, demonstrating that carbon-zinc bonds are not protonated by acidic phenols under the conditions of palladium-catalysed coupling reactions.
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