Continuous-flow synthesis of monoarylated acetaldehydes using aryldiazonium salts.
Natalia Chernyak, Stephen L Buchwald
Index: J. Am. Chem. Soc. 134(30) , 12466-9, (2012)
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Abstract
Anilines and ethyl vinyl ether can be used as precursors for a process that is the synthetic equivalent of the α-arylation of acetaldehyde enolate. The reaction manifests a high level of functional group compatibility, allowing the ready preparation of a number of synthetically valuable compounds.
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