Bioorganic & Medicinal Chemistry 2011-12-15

Synthesis and biological effects of some kynurenic acid analogs

K. Nagy, I. Plangár, B. Tuka, L. Gellért, D. Varga, I. Demeter, T. Farkas, Zs. Kis, M. Marosi, D. Zádori, P. Klivényi, F. Fülöp, I. Szatmári, L. Vécsei, J. Toldi

Index: Bioorg. Med. Chem. 19 , 7590-6, (2011)

Full Text: HTML

Abstract

This paper reports the synthesis of 10 new KYNA amides (KYNA-1–KYNA10) and on the effectiveness of this molecule as an inhibitor of excitatory synaptic transmission in the CA1 region of the hippocampus. The most effected molecule is newly synthetized KYNA-analogue (KYNA-1).

Related Compounds

Related Articles:

Effects of pro-inflammatory cytokines on expression of kynurenine pathway enzymes in human dermal fibroblasts.

2011-01-01

[J. Inflamm. (Lond.) 8 , 25, (2011)]

The L-kynurenine signalling pathway in trigeminal pain processing: a potential therapeutic target in migraine?

2011-07-01

[Cephalalgia 31 , 1029-1038, (2011)]

Inhibition of indoleamine 2,3-dioxygenase activity by levo-1-methyl tryptophan blocks gamma interferon-induced Chlamydia trachomatis persistence in human epithelial cells.

2011-11-01

[Infect. Immun. 79 , 4425-4437, (2011)]

Targeting the kynurenine pathway-related alterations in Alzheimer's disease: a future therapeutic strategy.

2011-01-01

[J. Alzheimers Dis. 24 , 199-209, (2011)]

KynR, a Lrp/AsnC-type transcriptional regulator, directly controls the kynurenine pathway in Pseudomonas aeruginosa.

2011-12-01

[J. Bacteriol. 193(23) , 6567-75, (2011)]

More Articles...