Novel methodology for the synthesis of N-alkoxyamines

R Braslau, A Tsimelzon, J Gewandter

Index: Braslau, Rebecca; Tsimelzon, Anna; Gewandter, Jennifer Organic Letters, 2004 , vol. 6, # 13 p. 2233 - 2235

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Citation Number: 38

Abstract

This new methodology offers a number of potential advantages over other methods. For instance, the use of toxic reagents such as hydrazine 3 or tin hydride 4 is avoided. One can readily prepare tert-butyl and i-propyl N-alkoxyamines, which are not possible by other methods. Furthermore, the method allows synthesis of N-alkoxyamines with hydroxyl and carboxyl functionalities. Incorporation of functionality on the N-alkoxyamine provides functional ...