Tetrahedron Letters

Highly efficient dynamic kinetic resolution of secondary aromatic alcohols with low-cost and easily available acid resins as racemization catalysts

Y Cheng, G Xu, J Wu, C Zhang, L Yang

Index: Cheng, Yongmei; Xu, Gang; Wu, Jianping; Zhang, Chensheng; Yang, Lirong Tetrahedron Letters, 2010 , vol. 51, # 17 p. 2366 - 2369

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Citation Number: 18

Abstract

A new and efficient dynamic kinetic resolution (DKR) process of secondary aromatic alcohols was developed with acid resins as racemization catalysts. Acid resin CD8604 was shown to have excellent racemization activity and good biocompatibility. When employing CD8604 and complex acyl donors as racemization catalyst and acyl donor, respectively, enantiomerically pure aromatic acetate was obtained with excellent yield and ee values ...