Organic letters

4-(N, N-Dimethylamino) pyridine hydrochloride as a recyclable catalyst for acylation of inert alcohols: substrate scope and reaction mechanism

Z Liu, Q Ma, Y Liu, Q Wang

Index: Liu, Zhihui; Ma, Qiaoqiao; Liu, Yuxiu; Wang, Qingmin Organic Letters, 2014 , vol. 16, # 1 p. 236 - 239

Full Text: HTML

Citation Number: 25

Abstract

4-(N, N-Dimethylamino) pyridine hydrochloride (DMAP· HCl), a DMAP salt with the simplest structure, was used as a recyclable catalyst for the acylation of inert alcohols and phenols under base-free conditions. The reaction mechanism was investigated in detail for the first time; DMAP· HCl and the acylating reagent directly formed N-acyl-4-(N′, N′- dimethylamino) pyridine chloride, which was attacked by the nucleophilic substrate to form ...