Alpha melanocyte stimulating hormone (-MSH) does not modify pentylenetetrazol- and pilocarpine-induced seizures.
FernandaRossatto Temp, AlineCarr_ Santos, JoseaneRighes Marafiga, AnaCl_udia Jesse, Qu_liFernandes Lenz, SaraMarquesan Oliveira, GustavoPetri Guerra, TeresaNieves Scimonelli, CarlosFernando Mello
Index: Life Sci. 93(20) , 723-31, (2013)
Full Text: HTML
Abstract
Alpha-melanocyte stimulating hormone (-MSH) is a pro-opiomelanocortin (POMC)-derived peptide involved in different neurological functions that also exerts anti-inflammatory effects, including in the central nervous system (CNS). Although inflammation has been implicated in seizures and epilepsy, no study has systematically investigated whether -MSH modifies seizures. Therefore, in the current study we determined whether -MSH alters pentylenetetrazol (PTZ)- and pilocarpine-induced seizures.
Related Compounds
Related Articles:
Chemical genetics reveals a complex functional ground state of neural stem cells.
2007-05-01
[Nat. Chem. Biol. 3(5) , 268-273, (2007)]
Function of inhibitory micronetworks is spared by Na+ channel-acting anticonvulsant drugs.
2014-07-16
[J. Neurosci. 34(29) , 9720-35, (2014)]
2013-01-01
[J. Biomed. Nanotechnol. 9(1) , 124-31, (2013)]
2014-07-01
[Exp. Neurol. 257 , 39-49, (2014)]
Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila.
2008-04-01
[Nat. Chem. Biol. 4 , 256-63, (2008)]