Beneficial effects of vildagliptin combined with miglitol on glucose tolerance and islet morphology in diet-controlleddb/dbmice

Keita Ishibashi, Akemi Hara, Yoshio Fujitani, Toyoyoshi Uchida, Koji Komiya, Motoyuki Tamaki, Hiroko Abe, Takeshi Ogihara, Akio Kanazawa, Ryuzo Kawamori, Hirotaka Watada

Index: Biochem. Biophys. Res. Commun. 440(4) , 570-5, (2013)

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Abstract

• Beneficial effects of combination therapy with vildagliptin plus miglitol on glucose tolerance of db/db mice were evaluated. • Postprandial glucose- and incretin response was normalized by the combination therapy. • Diabetes onset of db/db mice was prevented by the combination therapy. • Preservation of normal islet morphology seems to be the key for the beneficial effects.