Organic Letters 1999-12-02

Synthesis of trisubstituted alkenes via olefin cross-metathesis.

A K Chatterjee, R H Grubbs

Index: Org. Lett. 1 , 1751, (1999)

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Abstract

[formula: see text] Trisubstituted alkenes have been prepared for the first time via intermolecular olefin cross-metathesis, using 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene ruthenium alkylidene complexes 3a,b in good yields with moderate E selectivity. In addition, protected alcohols near the geminal disubstituted olefin improve reactivity for cross-metathesis.

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