Archives of Pharmacal Research 2006-01-01

Synthesis of diacetoxy acetal derivatives of santonin and their enhancing effects on HL-60 leukemia cell differentiation.

Seung Hyun Kim, Sun Young Chung, Tae Sung Kim, Bo Gil Choi

Index: Arch. Pharm. Res. 29(1) , 40-5, (2006)

Full Text: HTML

Abstract

Several diacetoxy acetal analogues have been synthesized from santonin and assessed for their ability of inducing or enhancing the differentiation of human HL-60 leukemia cells. The compounds themselves had little effect on HL-60 cell differentiation. However, three analogues, 2a, 3a, and 5b, synergistically enhanced 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3]-induced HL-60 cell differentiation when combined with 5 nM of dihydroxyvitamin D3 [1,25-(OH)2D3], a well-known differentiation inducer. Especially, the compound 5b profoundly enhanced the 1,25-(OH)2D3]-induced HL-60 cell differentiation.

Related Compounds

Related Articles:

The human bitter taste receptor TAS2R10 is tailored to accommodate numerous diverse ligands.

2013-01-02

[J. Neurosci. 33(1) , 201-13, (2013)]

Reversal of cocaine-induced planarian behavior by parthenolide and related sesquiterpene lactones.

2008-04-01

[Pharmacol. Biochem. Behav. 89(2) , 160-70, (2008)]

Diminutive effect on T and B-cell proliferation of non-cytotoxic α-santonin derived 1,2,3-triazoles: a report.

2013-02-01

[Eur. J. Med. Chem. 60 , 365-75, (2013)]

Chemical modification of santonin into a diacetoxy acetal form confers the ability to induce differentiation of human promyelocytic leukemia cells via the down-regulation of NF-kappaB DNA binding activity.

2006-05-12

[J. Biol. Chem. 281(19) , 13117-25, (2006)]

Santonin-related compound 2 inhibits the nuclear translocation of NF-κB subunit p65 by targeting cysteine 38 in TNF-α-induced NF-κB signaling pathway.

2012-01-01

[Biosci. Biotechnol. Biochem. 76(12) , 2360-3, (2012)]

More Articles...