Journal of Pharmaceutical and Biomedical Analysis 1999-01-01

Spectrofluorimetric determination of prenalterol hydrochloride in pharmaceutical preparations and biological fluids.

F A Aly

Index: J. Pharm. Biomed. Anal. 18(6) , 993-7, (1999)

Full Text: HTML

Abstract

A simple and highly sensitive fluorimetric method was developed for the routine determination of prenalterol hydrochloride in bulk, in dosage forms and in biological fluids. The method is based on the fluorescence induced by reaction of the nitroso-derivative of prenalterol hydrochloride with 2-cyanoacetamide in the presence of ammonia. The different experimental parameters were carefully studied and incorporated into the procedure. The fluorescence is measured at 440 nm after excitation at 368 nm. Fluorescence intensity is a linear function of prenalterol hydrochloride concentration over the range of 0.1-2.8 microg x ml(-1) in the solution finally measured. A proposal for the reaction pathway was suggested.

Related Compounds

Related Articles:

Diversity-oriented, one-pot, multi-component synthesis of substituted uracil derivatives.

2011-02-01

[Mol. Divers. 15(1) , 263-7, (2011)]

Controlled synthesis of Fe3O4/ZIF-8 nanoparticles for magnetically separable nanocatalysts.

2015-04-27

[Chemistry 21(18) , 6879-87, (2015)]

Acylation of heteroaromatic amines: facile and efficient synthesis of a new class of 1,2,3-triazolo[4,5-b]pyridine and pyrazolo[4,3-b]pyridine derivatives.

2011-01-01

[Molecules 16(5) , 3723-39, (2011)]

A novel α-isocyanoacetamide-based three-component reaction for the synthesis of dialkyl 2-acyl-5-aminofuran-3,4-dicarboxylates.

2011-03-07

[Org. Biomol. Chem. 9(5) , 1627-31, (2011)]

Kinetic and mechanistic analyses of new classes of inhibitors of two-component signal transduction systems using a coupled assay containing HpkA-DrrA from Thermotoga maritima.

2004-04-01

[Microbiology 150(Pt 4) , 885-96, (2004)]

More Articles...