Metalated methylenediphosphonate esters. Preparation, characterization and synthetic applications

OT Quimby, JD Curry, DA Nicholson, JB Prentice…

Index: Quimby,O.T. et al. Journal of Organometallic Chemistry, 1968 , vol. 13, p. 199 - 207

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Citation Number: 55

Abstract

The metalation of esters of tetraalkyl methylenediphosphonates with sodium, potassium, sodium hydride and n-butyllithium to form the corresponding salts, M + [ H(PO 3 R 2 ) 2 ], is described. These compounds were characterized by 31 P and 1 H NMR; their synthetic usefulness was demonstrated by the preparation of a variety of alkylates, R′CH(PO 3 R 2 ) 2 , and by the preparation of mono and dihalo derivatives, XCH(PO 3 R 2 ) 2 and X 2 C(PO 3 R 2 ) 2 , by ...