Lipase-mediated asymmetric construction of 2-arylpropionic acids: enantiocontrolled syntheses of S-naproxen and S-ibuprofen
T Bando, Y Namba, K Shishido
Index: Bando, Toshikazu; Namba, Yukiko; Shishido, Kozo Tetrahedron Asymmetry, 1997 , vol. 8, # 13 p. 2159 - 2165
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Citation Number: 35
Abstract
A general and enantiocontrolled synthetic route to 2-arylpropionic acids, represented by non- steroidal anti-inflammatory drugs S-naproxen 1a and S-ibuprofen 1b, has been developed by employing the lipase-mediated asymmetric acetylation of prochiral 2-aryl-1, 3- propanediol 3, which has been derived via a Heck reaction, as the key step.
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