Formation of 4-aminopyrimidines via the trimerization of nitriles using focused microwave heating.

Ian R Baxendale, Steven V Ley

Index: J. Comb. Chem. 7(3) , 483-9, (2005)

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Abstract

A series of substituted aliphatic nitriles have been trimerized to their corresponding pyrimidine structures under solvent-free conditions in the presence of catalytic quantities of potassium tert-butoxide using a focused microwave reactor. Multigram quantities of the corresponding 4-aminopyrimidines have been prepared in high yields and purity following a simple and scaleable protocol.