Antagonism of the discriminative effects of diazepam by pyrazoloquinolines in rats.
H E Shannon, S Herling
Index: Eur. J. Pharmacol. 92(1-2) , 155-7, (1983)
Full Text: HTML
Abstract
The diazepam-like agonist and diazepam antagonist properties of the pyrazoloquinoline benzodiazepine receptor ligands CGS8216, CGS9895 and CGS9896 were evaluated in rats trained to discriminate between saline and 1.0 mg/kg of diazepam in a two-choice, discrete-trial procedure. None of the three pyrazoloquinolines produced diazepam-like discriminative effects over the dose range of 1.0-30 mg/kg. The effects of 1.0 mg/kg of diazepam were antagonized by CGS8216 and CGS9895, but not by CGS9896. The present results provide behavioral evidence for benzodiazepine receptor heterogeneity.
Related Compounds
Related Articles:
Benzodiazepine receptor ligands modulate ethanol drinking in alcohol-preferring rats.
1994-09-22
[Eur. J. Pharmacol. 263(1-2) , 141-7, (1994)]
1994-01-01
[Med. Chem. Res. 4(5) , 307-14, (1994)]
1986-01-01
[Psychopharmacology 89(4) , 462-6, (1986)]
Differential diazepam-antagonist effects of the benzodiazepine receptor ligand CGS 9895 in rodents.
1985-12-01
[J. Pharmacol. Exp. Ther. 235(3) , 589-95, (1985)]
Pharmacology of the pyrazolo-type compounds: agonist, antagonist and inverse agonist actions.
1987-01-01
[Physiol. Behav. 41(3) , 241-5, (1987)]