Transition metal-free amination of aryl halides—A simple and reliable method for the efficient and high-yielding synthesis of N-arylated amines
JL Bolliger, CM Frech
Index: Bolliger, Jeanne L.; Frech, Christian M. Tetrahedron, 2009 , vol. 65, # 6 p. 1180 - 1187
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Citation Number: 33
Abstract
A simple and reliable reaction protocol for the clean, fast, and high-yielding synthesis of various N-arylated amines derived from reactions of aryl halides with various (also sterically hindered) amines under transition metal-free reaction conditions is presented. Dioxane and KN (Si (CH3) 3) 2 were found to be the ideal solvent and base for this transformation. The conversion rates and yields observed are excellent and in the majority of the reactions ...
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