Rapid and efficient microwave-assisted amination of electron-rich aryl halides without a transition-metal catalyst
L Shi, M Wang, CA Fan, FM Zhang, YQ Tu
Index: Shi, Lei; Wang, Min; Fan, Chun-An; Zhang, Fu-Min; Tu, Yong-Qiang Organic Letters, 2003 , vol. 5, # 19 p. 3515 - 3517
Full Text: HTML
Citation Number: 125
Abstract
A rapid and direct amination of aryl halides has been developed in good to high yields under microwave irradiation without a transition-metal catalyst. This reaction is a particularly powerful method for the coupling of electron-rich aryl halides with various amines. In some cases, the excellent regioselectivity could be observed, which facilitated the preparation of meta-substituted anilines from ortho-or para-substituted phenylhalides. In addition, a ...
Related Articles:
Solvent??Free Buchwald–Hartwig Reaction of Aryl and Heteroaryl Halides with Secondary Amines
[Topchiy, Maxim A.; Asachenko, Andrey F.; Nechaev, Mikhail S. European Journal of Organic Chemistry, 2014 , vol. 2014, # 16 p. 3319 - 3322]
[Pingsheng, Zhang; Shankar, Ashish; Cleary, Thomas P.; Cedilote, Miall; Locklear, Dobbert; Pierce, Michael E. Organic Process Research and Development, 2007 , vol. 11, # 5 p. 861 - 864]
[Zhou, Yanping; Xie, Yinjun; Yang, Lei; Xie, Pan; Huang, Hanmin Tetrahedron Letters, 2013 , vol. 54, # 21 p. 2713 - 2716]
SnCl 4 and SbCl 5 promoted aromatization of enamines
[Bigdeli, Mohammad Ali; Rahmati, Abbas; Abbasi-Ghadim, Hossein; Mahdavinia, Gholam Hossein Tetrahedron Letters, 2007 , vol. 48, # 26 p. 4575 - 4578]
[Bhadra, Sukalyan; Sreedhar, Bojja; Ranu, Brindaban C. Advanced Synthesis and Catalysis, 2009 , vol. 351, # 14-15 p. 2369 - 2378]