Novel Clarithromycin Analogs with C-4” 2-arylbenzimidazolyl Bishydrazide Side Chain: Synthesis and Antibacterial Evaluation

…, R Ma, X Li, Y Hu, S Ma, C Cong, X Ma…

Index: Qi, Yunkun; Ma, Ruixin; Li, Xin; Hu, Yue; Ma, Siti; Cong, Chao; Ma, Xiaodong; Cui, Wenping; Ma, Shutao Letters in Drug Design and Discovery, 2011 , vol. 8, # 10 p. 966 - 971

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Abstract

A series of novel 4”-O-2-arylbenzimidazolyl derivatives of clarithromycin were synthesized and evaluated. These 4”-O-2-arylbenzimidazolyl derivatives demonstrated excellent activity against erythromycin-susceptible strains and showed remarkably improved activity against erythromycin-resistant strains compared with the references. In particular, compound 7c, which possesses the terminal 2-(2-methoxyphenyl) benzimidazolyl group on the C-4” ...