Synthesis and antibacterial activity of novel 4 ″-O-benzimidazolyl clarithromycin derivatives

C Cong, H Wang, Y Hu, C Liu, S Ma, X Li, J Cao…

Index: Cong, Chao; Wang, Haiyang; Hu, Yue; Liu, Chen; Ma, Siti; Li, Xin; Cao, Jichao; Ma, Shutao European Journal of Medicinal Chemistry, 2011 , vol. 46, # 7 p. 3105 - 3111

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Citation Number: 13

Abstract

Abstract Novel 4 ″-O-benzimidazolyl clarithromycin derivatives were designed, synthesized and evaluated for their in vitro antibacterial activities. These benzimidazolyl derivatives exhibited excellent activity against erythromycin-susceptible strains better than the references, and some of them showed greatly improved activity against erythromycin- resistant strains. Compounds 16 and 17, which have the terminal 2-(4-methylphenyl) ...