Construction of a crown ether-like supramolecular library by conjugation of genetically-encoded peptide linkers displayed on bacteriophage T7.

Keisuke Fukunaga, Takaaki Hatanaka, Yuji Ito, Michiko Minami, Masumi Taki

Index: Chem. Commun. (Camb.) 50(30) , 3921-3, (2014)

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Abstract

By using the 10BASEd-T, we have synthesized a crown ether-like macrocyclic library possessing randomized peptide linkers on bacteriophage T7. Among 1.5 × 10(9) diversities of the supramolecule candidates, we have obtained a specific binder for the N-terminal domain of Hsp90.