In vivo biodistribution of platinum-based drugs encapsulated into multi-walled carbon nanotubes

Jian Li, Aakansha Pant, Chee Fei Chin, Wee Han Ang, Cécilia Ménard-Moyon, Tapas R. Nayak, Dan Gibson, Sundara Ramaprabhu, Tomasz Panczyk, Alberto Bianco, Giorgia Pastorin

Index: Nanomedicine: Nanotechnology, Biology, and Medicine 10(7) , 1465-75, (2014)

Full Text: HTML

Abstract

Carbon nanotubes (CNTs) are promising drug delivery systems due to their external functionalizable surface and their hollowed cavity that can encapsulate several bioactive molecules. In this study, the chemotherapeutic drug cisplatin or an inert platinum(IV) complex were entrapped inside functionalized-multi-walled-CNTs and intravenously injected into mice to investigate the influence of CNTs on the biodistribution of Pt-based molecules. The platinum levels in vital organs suggested that functionalized-CNTs did not affect cisplatin distribution, while they significantly enhanced the accumulation of Pt(IV) sample in some tissues (e.g. in the lungs, suggesting their potential application in lung cancer therapy) and reduced both kidney and liver accumulation (thus decreasing eventual nephrotoxicity, a typical side effect of cisplatin). Concurrently, CNTs did not induce any intrinsic abnormal immune response or inflammation, as confirmed by normal cytokine levels and histological evaluations. Therefore, functionalized nanotubes represent an efficient nano-carrier to improve accumulation of Pt species in targeted tissues/organs.