1,2-Dichloropropane: metabolism and fate in the rat.
A R Jones, J Gibson
Index: Xenobiotica 10(11) , 835-46, (1980)
Full Text: HTML
Abstract
1. The metabolism of 1,2-dichloropropane in the rat has been investigated. The major urinary metabolite has been isolated and identified as N-acetyl-S-(2-hydroxypropyl)cysteine. Two minor metabolites of 1,2-dichloropropane have been identified as beta-chlorolactate and N-acetyl-S-(2,3-dihydroxypropyl)cysteine. 2. The fate of 1-chloro-2-hydroxypropane, a proposed intermediate metabolite of 1,2-dichloropropane, has been investigated. Apart from its known urinary metabolite, N-acetyl-S-(2-hydroxypropyl)cysteine, two oxidative metabolites were detected. These were identified as beta-chlorolactaldehyde and beta-chlorolactate. 3. A pathway is proposed for the metabolism and fate of 1,2-dichloropropane in the rat. This accounts for previous observations made for the fate of radioactivity from administration of 1,2-dichloro[1-14C]propane. 4. The microbial and mammalian metabolism of several halogen-containing foreign compounds is discussed.
Related Compounds
Related Articles:
2003-01-01
[Natl. Toxicol. Program Tech. Rep. Ser. 477 , 1-264, (1998)]
1994-01-01
[Environ. Mol. Mutagen. 23(1) , 51-63, (1994)]
Haloperoxidases: Enzymatic Synthesis of alpha,beta-Halohydrins from Gaseous Alkenes.
1983-02-01
[Appl. Environ. Microbiol. 45(2) , 366-74, (1983)]
2006-01-01
[FEMS Microbiol. Ecol. 55(1) , 113-21, (2006)]
Reproductive toxicology. 1-Chloro-2-propanol.
1997-02-01
[Environ. Health Perspect. 105 Suppl 1 , 291-2, (1997)]