2-Substituted histamines with G-protein-stimulatory activity

…, A Hagelüken, R Seifert, W Schunack

Index: Detert, H.; Hagelueken, A.; Seifert, R.; Schunack, W. European Journal of Medicinal Chemistry, 1995 , vol. 30, # 4 p. 271 - 276

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Citation Number: 8

Abstract

The cationic-amphiphilic 2-substituted histamines, 2-(3-chlorophenyl) histamine (2-[2-(3- chlorophenyl)-1H-imidazol-4-yl] ethanamine) and 2-(2-cyclohexylethyl) histamine, activate pertussis toxin-sensitive guanine nucleotide-binding proteins (G-proteins) of the Gi- subfamily by a receptor-independent mechanism. We studied structure-activity relationships of 2-substituted histamine derivatives for this G-protein activation using six known and 12 ...