Metal-Free [2+ 2+ 1] Annulation of Alkynes, Nitriles, and Oxygen Atoms: Iodine (III)-Mediated Synthesis of Highly Substituted Oxazoles
A Saito, A Taniguchi, Y Kambara, Y Hanzawa
Index: Saito, Akio; Taniguchi, Akihiro; Kambara, Yui; Hanzawa, Yuji Organic Letters, 2013 , vol. 15, # 11 p. 2672 - 2675
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Citation Number: 37
Abstract
The metal-free [2+ 2+ 1] annulation of alkynes, nitriles, and O-atoms for the regioselective assembly of 2, 4-disubstituted and 2, 4, 5-trisubstituted oxazole compounds has been achieved by the use of PhIO with TfOH or Tf2NH. The present reaction could be applied to a facile synthesis of an anti-inflammatory drug.
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