Environmental-benign oxidation of 2-oxazolines to oxazoles by dioxygen as the sole oxidant
Y Huang, L Ni, H Gan, Y He, J Xu, X Wu, H Yao
Index: Huang, Yue; Ni, Lijun; Gan, Haifeng; He, Yu; Xu, Jinyi; Wu, Xiaoming; Yao, Hequan Tetrahedron, 2011 , vol. 67, # 11 p. 2066 - 2071
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Citation Number: 25
Abstract
A facile and environment-benign oxidation by dioxygen as the sole oxidant was applied for the conversion of 2-oxazolines to oxazoles. The substituent effect on 2-oxazoline ring was investigated. The use of this methodology for the synthesis of a key intermediate of a CDC25 phosphatase inhibitor (SC-ααδ9) as an anticancer agent was also described.
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