Salsalate is poorly tolerated and fails to improve endothelial function in virologically suppressed HIV-infected adults.

Corrilynn O Hileman, Teresa L Carman, Barbara M Gripshover, Maryann O'Riordan, Norma J Storer, Danielle E Harrill, Cynthia A White, Grace A McComsey

Index: AIDS 24(12) , 1958-61, (2010)

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Abstract

In this 13-week, open-label, randomized study of the anti-inflammatory salsalate versus usual care, there were no significant improvements in flow-mediated dilation of the brachial artery, endothelial activation, inflammation or coagulation markers, homeostasis model assessment of insulin resistance or lipoproteins with salsalate or between groups in virologically suppressed, HIV-infected adults on antiretrovirals. Tinnitus and transaminitis occurred frequently in the salsalate group. Dose reduction due to toxicities encountered and low level of inflammation may explain these results.