Facile synthesis of new substituted aryl and heteroarylflavones by thermal and microwave assisted Suzuki-Miyaura coupling reaction
V Joshi, J Govind Hatim
Index: Joshi, Vidya; Govind Hatim, Jaywant Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2012 , vol. 51, # 7 p. 1002 - 1010
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Abstract
Abstract: Microwave assisted Suzuki-Miyaura coupling of 4'-bromoflavone 5 with substituted aryl and heteroarylboronic acids 6a-m gives high yields of aryl and heteroarylflavones 7a-m. Couplings have been carried out by three methods i) conventional heating with Pd (OCOCH 3) 2 catalyst, in solvent DMF (N, N-dimethylformamide) and base, aqueous Na 2 CO 3 (2N) for 6-12 hr, at 110 C, yield 30-70%, ii) conventional heating with Pd [(C 6 H 5) 3 P] 4 ...
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