International journal of clinical and experimental pathology 2012-01-01

Knockdown of apoptosis repressor with caspase recruitment domain (ARC) increases the sensitivity of human glioma cell line U251MG to VM-26.

Qiong Wang, Ailin Li, Hong Wang, Jinhuan Wang

Index: Int. J. Clin. Exp. Pathol. 5(6) , 555-61, (2012)

Full Text: HTML

Abstract

Previous studies have demonstrated that apoptosis repressor with caspase recruitment domain (ARC) is up-regulated in many forms of malignant tumors and low levels of ARC protein were expressed in normal human brain tissue. Little is known expression of ARC in glioma. Here, we found that ARC protein was highly expressed in primary human glioma when compared with normal brain tissues. A decrease in cell viability and an increase in apoptosis were observed in U251MG cells after ARC was knocked down. Knockdown of ARC was confirmed by western blotting. Knockdown of ARC promoted caspase-8, caspase-3 activation and Bax accumulation. These results indicate that ARC has a anti-apoptosis function in glioma.

Related Compounds

Related Articles:

Pathologic risk-based adjuvant chemotherapy for unilateral retinoblastoma following enucleation.

2014-08-01

[J. Pediatr. Hematol. Oncol. 36(6) , e335-40, (2014)]

Action of db-cAMP on the bystander effect and chemosensitivity through connexin 43 and Bcl-2-mediated pathways in medulloblastoma cells.

2012-09-01

[Oncol. Rep. 28(3) , 969-76, (2012)]

Dose intensification of methotrexate and cytarabine during intensified continuation chemotherapy for high-risk B-precursor acute lymphoblastic leukemia: POG 9406: a report from the Children's Oncology Group.

2014-07-01

[J. Pediatr. Hematol. Oncol. 36(5) , 353-61, (2014)]

A cremophor-free self-microemulsified delivery system for intravenous injection of teniposide: evaluation in vitro and in vivo.

2012-09-01

[AAPS PharmSciTech 13(3) , 846-52, (2012)]

Study on clinical therapeutic effect including symptoms, eye preservation rate, and follow-up of 684 children with retinoblastoma.

2013-01-01

[Eur. J. Ophthalmol. 23(4) , 532-8, (2013)]

More Articles...