Bioorganic & Medicinal Chemistry 1994-04-01

The functionalisation of saturated hydrocarbons--XXX. Model studies on the mechanism of some oxygenases.

D H Barton, C O Bardin, D Doller

Index: Bioorg. Med. Chem. 2(4) , 259-66, (1994)

Full Text: HTML

Abstract

In harmony with our studies on the activation of hydrocarbons by Gif chemistry, we have, in the first part of this paper, studied the mechanism of the lipoxygenase enzymes using soybean lipoxygenase as a model. We have shown with trimethyl phosphite that no free radical is released by the enzyme. In a second part, we have studied the mechanism of the alpha-ketoglutarate dependent enzymes and shown evidence for a mechanism involving the reduction of an intermediate hydroperoxide by the alpha-ketoglutaric acid.

Related Compounds

Related Articles:

Interactions of multitargeted kinase inhibitors and nucleoside drugs: Achilles heel of combination therapy?

2015-01-01

[J. Chromatogr. A. 1421 , 154-61, (2015)]

Rapid modification of the insect elicitor N-linolenoyl-glutamate via a lipoxygenase-mediated mechanism on Nicotiana attenuata leaves.

2010-01-01

[BMC Plant Biol. 10 , 164, (2010)]

Surface characterization and platelet adhesion studies of plasma polymerized phosphite and its copolymers with dimethylsulfate.

1999-08-01

[Biomaterials 20(16) , 1439-47, (1999)]

Trimethyl phosphite as a trap for alkoxy radicals formed from the ring opening of oxiranylcarbinyl radicals. Conversion to alkenes. Mechanistic applications to the study of C-C versus C-O ring cleavage.

2003-03-19

[J. Am. Chem. Soc. 125(11) , 3248-59, (2003)]

Teratological evaluation of trimethyl phosphite in the rat.

1984-01-01

[Toxicol. Appl. Pharmacol. 72(1) , 119-23, (1984)]

More Articles...