Synthesis and cytotoxic evaluation of quinazolin-4 (3H)-one derivatives bearing thiocarbamate, thiourea or N-methyldithiocarbamate side chains

SL Cao, H Xu, Y Wang, J Liao, JJ Zhang…

Index: Cao, Sheng-Li; Xu, Hong; Wang, Yao; Liao, Ji; Zhang, Jing-Jing; Li, Zhong-Feng; Guo, Yan-Wen; Li, Xiao-Rong; Cui, Xue-Mei; Xu, Xingzhi Medicinal Chemistry, 2012 , vol. 8, # 2 p. 163 - 173

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Abstract

We have previously found that the dithiocarbamate derivatives of quinazolin-4 (3H)-one could act as cytotoxic agents against a panel of human tumor cell lines. To investigate the contribution of dithiocarbamate moiety to the cytotoxic activity, three series of novel quinazolin-4 (3H)-one derivatives bearing thiocarbamate, thiourea or Nmethyldithiocarbamate side chains were synthesized and tested for their cytotoxic ...