HIV-1 clade C envelopes obtained from late stage symptomatic Indian patients varied in their ability towards relative CD4 usages and sensitivity to CCR5 antagonist TAK-779

Lavina Gharu, Rajesh Ringe, Jayanta Bhattacharya, Lavina Gharu, Rajesh Ringe, Jayanta Bhattacharya, Lavina Gharu, Rajesh Ringe, Jayanta Bhattacharya

Index: Virus Res. 158(1-2) , 216-24, (2011)

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Abstract

Highlights ► Compared envelopes with expanded coreceptor tropism with those that are strictly CCR5 using for their capacity to utilize CD4 and CCR5. ► Low CD4 dependent envelopes infect primary cells better than those that required optimum CD4 for entry ► No association between low CD4 usage and sensitivity to TAK-779 ► Envelopes with low CD4 usage showed relative resistance to T-20 ► Data throw important insight in disease transmission in late stage in context of subtype C HIV-1 variants.