In vitro antioxidant and anti-inflammatory activities of 1-dehydro-[6]-gingerdione, 6-shogaol, 6-dehydroshogaol and hexahydrocurcumin.
Feng Li, Viriya Nitteranon, Xiaozhen Tang, Jin Liang, Guodong Zhang, Kirk L Parkin, Qiuhui Hu
Index: Food Chem. 135(2) , 332-7, (2012)
Full Text: HTML
Abstract
Hexahydrocurcumin, 1-dehydro-[6]-gingerdione, 6-dehydroshogaol and 6-shogaol were evaluated for their antioxidant and anti-inflammatory activities in the present study. The relative antioxidant potencies of ginger compounds decreased in similar order of 1-dehydro-[6]-gingerdione, hexahydrocurcumin>6-shogaol>6-dehydroshogaol in both 1,1-diphenyl-2-picyrlhydrazyl (DPPH) radical-scavenging and trolox equivalent antioxidant capacity (TEAC) assays. All tested compounds could attenuate lipopolysaccharide (LPS)-elicited increase of prostaglandin E2 (PGE(2)) in murine macrophages (RAW 264.7) in a concentration-dependent manner but hexahydrocurcumin of 7μM and 6-shogaol of 7μM. The strongest inhibitory effect was observed for 6-dehydroshogaol and 6-shogaol at 14μM with the inhibition of 53.3% and 48.9%, respectively. Furthermore, both 6-dehydroshogaol and 1-dehydro-[6]-gingerdione significantly suppressed the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins in a concentration-dependent fashion. These results contribute to our theoretical understanding of the potential beneficial effects of consuming ginger as a food and/or dietary supplement.Copyright © 2012 Elsevier Ltd. All rights reserved.
Related Compounds
Related Articles:
Oxidative stress influences positive strand RNA virus genome synthesis and capping.
2015-01-15
[Virology 475 , 219-29, (2014)]
2014-09-01
[Naunyn Schmiedebergs Arch. Pharmacol. 387(9) , 849-59, (2014)]
Lignin Modification for Biopolymer/Conjugated Polymer Hybrids as Renewable Energy Storage Materials.
2015-12-07
[ChemSusChem 8 , 4081-5, (2015)]
Propofol increases morbidity and mortality in a rat model of sepsis.
2015-01-01
[Crit. Care 19 , 45, (2015)]
2015-04-01
[Int. J. Biol. Macromol. 75 , 58-66, (2015)]