Synthesis and liposome encapsulation of a novel 18F??conjugate of ω??conotoxin GVIA for the potential imaging of N??type Ca2+ channels in the brain by positron …
…, A Gangloff, Y Seimbille, S Delaloye…
Index: Azarian, Vahe; Gangloff, Anne; Seimbille, Yann; Delaloye, Sibylle; Czernin, Johannes; Phelps, Michael E.; Silverman, Daniel H. S. Journal of Labelled Compounds and Radiopharmaceuticals, 2006 , vol. 49, # 3 p. 269 - 283
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Citation Number: 10
Abstract
Abstract ω-Conotoxin GVIA is a potent, irreversible antagonist of N-type voltage gated Ca 2+ channels. A radiofluorinated analogue of GVIA could be useful in assessing regional synaptic density of the brain, in vivo, using positron emission tomography. N-hydroxy succinimidyl 4-[18 F] fluorobenzoate was employed to site-specifically label GVIA, preserving native binding affinity. The tracer was characterized with MALDI-TOF mass ...
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