Three-component coupling using arynes and DMF: straightforward access to coumarins via ortho-quinone methides.

Hiroto Yoshida, Yu Ito, Joji Ohshita

Index: Chem. Commun. (Camb.) 47(30) , 8512-4, (2011)

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Abstract

ortho-Quinone methides, arising from a formal [2+2] cycloaddition between arynes and DMF, were found to facilely undergo a [4+2] cycloaddition with ester enolates or ketenimine anions to produce diverse coumarins in a straightforward manner.This journal is © The Royal Society of Chemistry 2011