Food and Chemical Toxicology 2011-01-01

Obacunone and obacunone glucoside inhibit human colon cancer (SW480) cells by the induction of apoptosis

K.N. Chidambara Murthy, G.K. Jayaprakasha, Bhimanagouda S Patil, K.N. Chidambara Murthy, G.K. Jayaprakasha, Bhimanagouda S Patil

Index: Food Chem. Toxicol. 49(7) , 1616-25, (2011)

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Abstract

Highlights ► Isolated and Identified obacunone and obacunone glucoside from Marsh White grapefruits for the first time. ► Inhibition of human colon cancer cell (SW480) proliferation was reported for the first time. ► Possible mode of apoptosis induction by limonoids in human colon cancer cells. ► Combining limonoids with camptothecin demonstrated additive apoptosis was observed in colon cancer cells.

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